HCID 70107479, compound → HCID 70108487, compound

Participants

Reaction Steps

2-tert-Butoxycarbonylaminoacetyl-7-(4-fluorophenyl)-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (50 mg) was dissolved in trifluoroacetic acid (0.5 ml). The solution was stirred at ambient temperature for 30 minutes and concentrated in vacuo. The residue was dissolved in water and the solution was neutralized with an aqueous saturated sodium bicarbonate solution. The separated oil was extracted with a mixture of dichloromethane and ethanol (7:3) and the extract was washed with water, dried and concentrated in vacuo. The residue was crystallized from ethyl acetate to give 2-aminoacetyl-7-(4-fluorophenyl)-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (30 mg).

Provenance & Evidence