Sulfuric Acid → HCID 70108655, compound

Participants

Reaction Steps

To a suspension of 7-(4-fluorophenyl)-2-phenylglyoxyloyl-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (2.778 g) in a mixture of ethanol (14 ml) and ethyl acetate (10 ml) was added conc. sulfuric acid (0.67 g). To the resulting clear solution was added ethyl acetate (30 ml) and the solution was stirred at ambient temperature for 4 hours. The separated solid was collected and recrystallized from aqueous acetonitrile to give 7-(4-fluorophenyl)-2-phenylglyoxyloyl-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine sulfate (2.7 g).

Provenance & Evidence