Pyridinium chloride → HCID 22909362, compound

HRID 1379042Notes

Reaction equation

HRID 1379042 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]2[C:29](=[O:30])[C:28]3[CH:31]=[CH:32][CH:33]=[C:26]4[C:27]=3[C:22](=[CH:23][CH:24]=[CH:25]4)[C:21]2=[O:34])[CH2:14][CH2:13]1.Cl.N1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][N:20]2[C:29](=[O:30])[C:28]3[CH:31]=[CH:32][CH:33]=[C:26]4[C:27]=3[C:22](=[CH:23][CH:24]=[CH:25]4)[C:21]2=[O:34])[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 22909352HCID 22909352, compound

Product 1

HCID 22909362HCID 22909362, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1.6 g of 2-[2-(4-(5-methoxy-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione [which can be prepared according to Example 1], 1.8 g of pyridine hydrochloride and 50 ml of pyridine is boiled for 3 hours. The mixture is cooled, evaporated, worked up in the customary manner and gives 2-[2-(4-(5-hydroxy-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione.

Workup

  1. temperatureThe mixture is cooled
  2. customevaporated

Sources & evidence

ORD record
ord-5dcdbe4c4a0149ed8caee7769b109fb5
Source dataset
uspto-grants-1997_09
Patent number
US05670511

Reaction notes

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