Methylamine → HCID 22909775, compound

Participants

Reaction Steps

0.10 g (0.23 mmol) of N-{3-(3,4-dimethylphenyl)propyl}-4-(2-bromoethoxy)-3-methoxyphenylacetamide obtained in step 1 of Example 2 and a catalytic amount of dimethylaminopyridine were dissolved in 50 ml of tetrahydrofuran and 0.048 g (0.35 mmol) of potassium carbonate was added thereto. Then, methylamine was passed through the mixture by bubbling at the temperature ranging from -10° to -20° C. The resultant mixture was stirred at a room temperature for 6 hours. After removing the solvent under a reduced pressure, the residue was subjected to silica gel column chromatography(eluent: ethyl acetate:hexane= 1:1) to obtain the title compound.

Provenance & Evidence