HRID13792

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23145897

未命名化合物

结构：CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)O)cc2C(F)(F)F)CC1

HCID23145899

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(CN3CCN(C(=O)OC(C)(C)C)CC3)c(C(F)(F)F)c2)cc1Nc1cc(-c2cccnc2)ccn1

HCID23145903

未命名化合物

PROCEDURE

实验过程

This compound was prepared in the same manner as in Example 34, except that 4-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethylbenzoic acid (Reference Example 13) and 4-methyl-3-[4-(3-pyridyl)pyridin-2-ylamino]aniline (Reference Example 23) were used, and that the resulting crude crystals obtained by purification with silica gel column chromatography were recrystallized from n-hexane-ethyl acetate.

WORKUP

后处理

customthat the resulting crude crystals obtained by purification with silica gel column chromatography
customwere recrystallized from n-hexane-ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8c9c926dc07943ca8809ce8579aee055
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07728131B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][C:16]=2[C:24]([F:27])([F:26])[F:25])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:28][C:29]1[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][C:30]=1[NH:36][C:37]1[CH:42]=[C:41]([C:43]2[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=2)[CH:40]=[CH:39][N:38]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([NH:33][C:32]3[CH:34]=[CH:35][C:29]([CH3:28])=[C:30]([NH:36][C:37]4[CH:42]=[C:41]([C:43]5[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=5)[CH:40]=[CH:39][N:38]=4)[CH:31]=3)=[O:21])=[CH:17][C:16]=2[C:24]([F:27])([F:26])[F:25])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]