4-Methyl-3-[4-(3-pyridyl)pyridin-2-ylamino]aniline → 4-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethyl-N-{4-methyl-3-[4-(3-pyridyl)pyridin-2-ylamino]phenyl}benzamide
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][C:16]=2[C:24]([F:27])([F:26])[F:25])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:28][C:29]1[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][C:30]=1[NH:36][C:37]1[CH:42]=[C:41]([C:43]2[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=2)[CH:40]=[CH:39][N:38]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([NH:33][C:32]3[CH:34]=[CH:35][C:29]([CH3:28])=[C:30]([NH:36][C:37]4[CH:42]=[C:41]([C:43]5[CH:44]=[N:45][CH:46]=[CH:47][CH:48]=5)[CH:40]=[CH:39][N:38]=4)[CH:31]=3)=[O:21])=[CH:17][C:16]=2[C:24]([F:27])([F:26])[F:25])[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]Participants
3
Reactant 2
Product 1
Procedure
This compound was prepared in the same manner as in Example 34, except that 4-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethylbenzoic acid (Reference Example 13) and 4-methyl-3-[4-(3-pyridyl)pyridin-2-ylamino]aniline (Reference Example 23) were used, and that the resulting crude crystals obtained by purification with silica gel column chromatography were recrystallized from n-hexane-ethyl acetate.
Workup
- customthat the resulting crude crystals obtained by purification with silica gel column chromatography
- customwere recrystallized from n-hexane-ethyl acetate
Sources & evidence
- ORD record
- ord-8c9c926dc07943ca8809ce8579aee055
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07728131B2
Reaction notes
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