HCID 86751305, compound → HCID 86751304, compound

Participants

Reaction Steps

A mixture of (2R)-4-[3-(benzyloxycarbonyl)propyl]-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-yl-methyl)piperazine (0.15 g), 10% Pd charcoal (15 mg) and methanol (4.5 ml) was stirred for 3 hours under hydrogen atmosphere (1 atm). The catalyst was removed by filtration and the filtrate was concentrated. The residue was purified by column chromatography on a silica gel using chloroform-methanol (5:1) as eluent to give (2R)-4-(3-carboxypropyl)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-yl-methyl)piperazine (0.067 g) as a powder.

Provenance & Evidence