tert-Butyl isocyanate → HCID 54056764, compound

Participants

Reaction Steps

t-Butylisocyanate (0.093 g) and triethylamine (0.095 g) were added successively to a stirred solution of 4-chloro-2-hydroxy-N(3-trifluoromethylphenyl)butanamide (0.24 g, prepared as described in Example 10, Step 1a above). After a day further aliquots of t-butylisocyanate and triethylamine were added. After a further twenty hours, the mixture was evaporated under reduced pressure and the residue chromatographed under reduced pressure to give the title compound (0.13 g, m.p. 115°-116° C.). NMR (CDCl3): δ 1.4(9H,s); 2.4(2H,m); 3.65(1H,t); 5.0(1H,bs); 5.35(1H,t); 7.35(2H,m); 7.7(1H,d); 7.8(1H,s); 8.6(1H,bs). MS: MH+ 381, 383.

Provenance & Evidence