Triethylamine → HCID 22909959, 화합물

HRID 1379284노트

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HRID 1379284 반응식
[Br:1][CH2:2][CH2:3][CH:4]([OH:18])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=1)=[O:6].[C:19]([N:23]=[C:24]=[O:25])([CH3:22])([CH3:21])[CH3:20].C(N(CC)CC)C>ClCCl>[Br:1][CH2:2][CH2:3][CH:4]([O:18][C:24](=[O:25])[NH:23][C:19]([CH3:22])([CH3:21])[CH3:20])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:16])[F:17])[CH:9]=1)=[O:6]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 62412tert-Butyl isocyanateHCID 229099674-bromo-2-hydroxy-N(3-trifluoromethylphenyl)butanamide

생성물 1

HCID 22909959HCID 22909959, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

By a procedure similar to that described in Step 1a above, 4-bromo-2-hydroxy-N(3-trifluoromethylphenyl)butanamide (0.52 g, prepared as described in Example 10, Step 1b above) was treated with t-butylisocyanate and triethylamine in dichloromethane to give the title compound (0.03 g, m.p. 107°-109° C.). NMR (CDCl3): δ 1.4(9H,s); 2.4(2H,m); 3.6(2H,t); 5.1(1H,bs); 5.3(1H,t); 7.3(2H,m); 7.6(1H,d); 7.8(1H,bs); 8.8(1H,bs). MS: M+ 424, 426. Under the extended time of this reaction, the major product was that of base-catalysed cyclisation (0.16 g, m.p. 114°-116° C.), identical to material described in Example 10, Step 3 above and Example 11, Step 2 below.

출처 및 근거

ORD 기록
ord-02a2220f95ce4646840c16d2e44e40fe
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05670656

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