Water → HCID 22909977, compound

Participants

Reaction Steps

Sodium iodide (1.1 g), followed by ethylamine (1.92 ml) was added to a solution in tetrahydrofuran (60 ml) of the ethylamino compound prepared in Step 2 (2.6 g). The solution was stirred for two hours and then left to stand overnight. The reaction mixture was then poured into water and extracted with ethyl acetate three times. The extracts were combined, washed twice with water and once with brine, dried (magnesium sulphate), and concentrated to yield a dark brown oil. This was chromatographed on a silica column using a mixture of triethylamine and ethyl acetate (1:9) as the eluent. The title compound was obtained as a yellow solid. The NMR spectrum was consistent with the expected structure.

Provenance & Evidence