HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 2-Methyl-1-naphthol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Boronic Acid | HCID 61668 | — |
| Reactant | 1-Bromo-2-methylnaphthalene | HCID 75754 | — |
| Reactant | (2-methylnaphthalen-1-yl)boronic Acid | HCID 11401196 | — |
| Product | 2-Methyl-1-naphthol | HCID 24055 | 51% |
Reaction Steps
Yarboro, T. L.; Karr, C.; J. Org. Chem. 1959, 24, 1141 disclose a process wherein 1-bromo-2-methyl naphthalene is convened into 2-methyl-1-naphthalene boronic acid via Grignard reaction. The boronic acid is oxidized by 30% hydrogen peroxide to produce 2-methyl-1-naphthol in 51% yield. This prior art process is disadvantageous in that it involves 4 steps and is not economical.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05670698 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-bc2e5f0c465649e78684c16d15779377 |
| Source note | uspto-grants-1997_09 |