2-(Methylamino)ethanol → N-Cbz-N-methyl-2-aminoethanol

Participants

Reaction Conditions

Reaction Steps

To N-methylethanolamine (149 mmol) in methylene chloride (100 ml) at 0° C. was added benzyl chloroformate (70 mmol). The mixture was stirred at 0° C. for 30 min, then at room temperature for 1 h, poured into ethyl acetate, washed with 2M HCl, saturated NaHCO3 solution, and brine, then dried over Na2SO4 and evaporated to provide the desired compound. 1H NMR (CDCl3,TMS) δ 7.36 (m, 5H), 5.14 (s,2H), 3.78 (m, 2H), 3.47 (m, 2H), 3.01 (s, 3H).

Provenance & Evidence