HRID1379378

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13524712

未命名化合物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)C(F)Cc1ccccc1

HCID22864453

未命名化合物

PRODUCTS

生成物

HCID22864454

未命名化合物

PROCEDURE

实验过程

According to the procedure of Thaisrivongs et. al. (J. Med. Chem. 1986, 29, 2080), the resultant compound of Example 128 was oxidized with oxalyl chloride/dimethyl sulfoxide to provide the desired compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b2260df9707a45609838e041b820b148
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05670675
来源说明: uspto-grants-1997_09

反应 SMILES

[C:1]([NH:11][C@H:12]([C:16]([NH:18][CH:19]([CH:27]([OH:37])[CH:28]([F:36])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])[CH:13]([CH3:15])[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C(Cl)(=O)C(Cl)=O.CS(C)=O>>[C:1]([NH:11][C@H:12]([C:16]([NH:18][CH:19]([C:27](=[O:37])[CH:28]([F:36])[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:17])[CH:13]([CH3:14])[CH3:15])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]