HCID 13524712, compound → HCID 22864454, compound

HRID 1379378Notes

Reaction equation

HRID 1379378 reaction equation
[C:1]([NH:11][C@H:12]([C:16]([NH:18][CH:19]([CH:27]([OH:37])[CH:28]([F:36])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:17])[CH:13]([CH3:15])[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C(Cl)(=O)C(Cl)=O.CS(C)=O>>[C:1]([NH:11][C@H:12]([C:16]([NH:18][CH:19]([C:27](=[O:37])[CH:28]([F:36])[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:17])[CH:13]([CH3:14])[CH3:15])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Participants

3

Reactant 2

HCID 13524712HCID 13524712, compoundHCID 22864453HCID 22864453, compound

Product 1

HCID 22864454HCID 22864454, compound

Procedure

According to the procedure of Thaisrivongs et. al. (J. Med. Chem. 1986, 29, 2080), the resultant compound of Example 128 was oxidized with oxalyl chloride/dimethyl sulfoxide to provide the desired compound.

Sources & evidence

ORD record
ord-b2260df9707a45609838e041b820b148
Source dataset
uspto-grants-1997_09
Patent number
US05670675

Reaction notes

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