Isovaleryl chloride → (4S)-4-Benzyl-3-isovaleryloxazolidin-2-one

HRID 1379404Notes

Reaction equation

HRID 1379404 reaction equation
[CH2:1]([CH:8]1[CH2:12][O:11][C:10](=[O:13])[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14](Cl)(=[O:19])[CH2:15][CH:16]([CH3:18])[CH3:17]>>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:19])[CH2:15][CH:16]([CH3:18])[CH3:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 66054Isovaleryl chlorideHCID 5596684-Benzyl-1,3-oxazolidin-2-one

Product 1

HCID 11108107(4S)-4-Benzyl-3-isovaleryloxazolidin-2-one

Procedure

Using the procedure of Example 100A but replacing 4-(2-propyl)-oxazolidine-2-one with 4-benzyloxazolidine-2-one and replacing 4-methylpentanoyl chloride with isovaleryl chloride provided the desired compound.

Sources & evidence

ORD record
ord-ef85676adf444fa5a75b67c90cee9467
Source dataset
uspto-grants-1997_09
Patent number
US05670675

Reaction notes

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