Methyl iodide → HCID 54223889, compound

HRID 1379478Notes

Reaction equation

HRID 1379478 reaction equation
[CH3:1][C@@:2]12[C:11]3[CH:12]=[CH:13][C:14]([S:16][C:17]4[CH:26]=[CH:25][C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH:18]=4)=[CH:15][C:10]=3[CH2:9][CH2:8][C@H:7]1[NH:6][C:5](=[O:27])[CH2:4][CH2:3]2.[CH3:28]I>>[CH3:28][N:6]1[C@H:7]2[C@@:2]([CH3:1])([C:11]3[CH:12]=[CH:13][C:14]([S:16][C:17]4[CH:26]=[CH:25][C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH:18]=4)=[CH:15][C:10]=3[CH2:9][CH2:8]2)[CH2:3][CH2:4][C:5]1=[O:27]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 53990882HCID 53990882, compound

Product 1

HCID 54223889HCID 54223889, compound

Procedure

A 282 mg portion of (4aR)-(10bR)-10b-methyl-8-(2-naphthylthio)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one was methylated with methyl iodide following the process of Example 95 to obtain 137 mg of the desired product. mp 138°-139.5° FDMS: m/e=387. α[D]589 =+69.6, α[D]365 =+261.4 (chloroform).

Sources & evidence

ORD record
ord-f2a1a71946b84027a3d928a236475a87
Source dataset
uspto-grants-1997_09
Patent number
US05670514

Reaction notes

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