Sodium Iodide → HCID 129844758, compound

Participants

Reaction Conditions

Reaction Steps

5 g of sodium iodide (Aldrich) is added to a solution of 1-chloromethyl carbonate (3) in 50 ml of acetone (Aldrich), and the reaction mixture is stirred at 50° C. for 24 h. After stirring overnight, the solvent is evaporated and the residue is redissolved in diethyl ether (Fisher). The ether layer is washed successively with 10% aqueous sodium sulfite and then water, and dried over anhydrous Na2SO4. The ether layer is separated and evaporated to give 1-iodomethyl p-nitrophenol carbonate (4) as a yellow oil which is confirmed by NMR. 1H-NMR (CDCl3): 6.03 (2H, s), 7.39 (2H, d, J=9 Hz), 8.24 (2H, d, J=9 Hz).

Provenance & Evidence