HRID13796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9965429

4-Methyl-N~3~-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine

C16H15N5

结构：CN1CCC(Oc2ccc(C(=O)Cl)cc2C(F)(F)F)CC1.Cl

HCID23145894

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(OC3CCN(C)CC3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1

HCID11376424

未命名化合物

PROCEDURE

实验过程

This compound was prepared in the same manner as in Example 1, except that 4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline (Patent Document 1) and 4-(1-methylpiperidin-4-yloxy)-3-trifluoromethylbenzoyl chloride hydrochloride (Reference Example 11) were used.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-abef090c3a5a45098ce3938ea325d5ea
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07728131B2
来源说明: uspto-grants-2010_06

反应 SMILES

[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]=[C:14]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[CH:13]=[CH:12][N:11]=1.Cl.[CH3:23][N:24]1[CH2:29][CH2:28][CH:27]([O:30][C:31]2[CH:39]=[CH:38][C:34]([C:35](Cl)=[O:36])=[CH:33][C:32]=2[C:40]([F:43])([F:42])[F:41])[CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:25][CH2:26][CH:27]([O:30][C:31]2[CH:39]=[CH:38][C:34]([C:35]([NH:6][C:5]3[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([NH:9][C:10]4[N:15]=[C:14]([C:16]5[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=5)[CH:13]=[CH:12][N:11]=4)[CH:4]=3)=[O:36])=[CH:33][C:32]=2[C:40]([F:41])([F:42])[F:43])[CH2:28][CH2:29]1