HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1379663Generated: November 1, 2026
Acetic Anhydride → (1-Acetylpiperidin-4-yl)acetic acid
https://huagongshe.com/reaction/1379663
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-Piperidineacetic acid | HCID 1512594 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-Acetylpiperidin-4-yl)acetic acid | HCID 10442408 | 99% |
Reaction Steps
4-Piperidinylacetic acid (5 grams) (35.0 mmoles) was reacted with acetic anhydride (10.7 grams) (105.0 mmoles) in MeOH (100 ml.) and the mixture was stirred at 25° C. for 24 hours. The mixture was evaporated to dryness and the residue was azeotroped with toluene to give the title compound (Yield: 6.4 grams, 99%, MH+ 185).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05672611 |
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| Source dataset | uspto-grants-1997_09 |
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| ORD ID | ord-433530df20854e2ea0e339893385ba9d |
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| Source note | uspto-grants-1997_09 |
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