3-Pyridineacetic acid → 3-Piperidineacetic acid

HRID 1379665Notes

Reaction equation

HRID 1379665 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:3]=1.N1C=CC=C(CC(O)=O)C=1>>[NH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][C:9]([OH:11])=[O:10])[CH2:3]1

Participants

3

Reactant 2

HCID 1083-Pyridineacetic acidHCID 27237243-Pyridineacetic acid, hydrochloride (1:1)

Product 1

HCID 2836963-Piperidineacetic acidYield 80.5%

Procedure

3-Pyridylacetic acid hydrochloride (13 grams) (74.9 mmoles) was hydrogenated as described in Preparative Example 5A to give a mixture of unreacted 3-pyridylacetic acid and the title compound (76:24) (8.63 grams, MH+ 144).

Workup

  1. customto give

Sources & evidence

ORD record
ord-2e06b6cd417243319cea40ab3015f962
Source dataset
uspto-grants-1997_09
Patent number
US05672611

Reaction notes

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