Hydroxyamine hydrochloride → HCID 18923777, compound

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Reaction Steps

The 1-(4-benzyloxyphenyl)-2-(4-methoxyphenyl)-5-(4-fluorophenyl)pentan-1,5-dione (1.0 g, 2.4 mmol) and hydroxylamine hydrochloride (0.2 g, 2.9 mmol) were refluxed in 30 mL of MeOH for 48 h, worked up, and purified to give 0.45 g (40 % yield) of product: mp 114°-115° C.; 1H NMR (CDCl3) d 3.82 (s, 3H, OCH3), 5.06 (s, 2H, OCH2Ar), 6.83-6.89 (m, 4H, ArH), 7.13-7.19 (m, 4H, ArH), 7.34-7.44 (m, 7H, ArH), 7.65-7.74 (dd, 2H, J=8, ArH), 8.10-8.14 (m, 2H, ArH); MS(FD) 461(M+). Anal. Calcd for C31H24NO2F: C, 80.67; H, 5.24; N,3.03. Found: C, 80.87; H, 5.30; N, 3.09.

Provenance & Evidence