Pyrrolidine → HCID 22907290, compound

Participants

Reaction Steps

To a solution of ethyl 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran-5-carboximidic acid hydrochloride (400 mg, 1.29 mmol) in dioxane (10 mL) is added excess pyrrolidine (0.6 mL). A color change from red to yellow is observed during the addition, and a precipitate forms. The reaction is also monitored by TLC (10% MeOH/CHCl3). After 3 h, the yellow precipitate is collected by filtration and purified by preparative TLC (10% MeOH/CHCl3) to give the desired product as a white powder (210 mg, 54.2%), mp=255°-256° C.

Provenance & Evidence