Thymidine → 5'-O-(4,4'-Dimethoxytrityl)thymidine

HRID 1379767Notes

Reaction equation

HRID 1379767 reaction equation
[C@@H:1]1([N:9]2[CH:17]=[C:15]([CH3:16])[C:13](=[O:14])[NH:12][C:10]2=[O:11])[O:8][C@H:5]([CH2:6][OH:7])[C@@H:3]([OH:4])[CH2:2]1.N#N.C([C@@]1(N2C3N=C(N)NC(=O)C=3N=C2)O[C@H](CO[C:32]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][CH:42]=2)[C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[C@@H](O)C1)(=O)C(C)C>>[CH3:48][O:47][C:44]1[CH:43]=[CH:42][C:41]([C:32]([O:7][CH2:6][C@H:5]2[O:8][C@@H:1]([N:9]3[CH:17]=[C:15]([CH3:16])[C:13](=[O:14])[NH:12][C:10]3=[O:11])[CH2:2][C@@H:3]2[OH:4])([C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)[C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)=[CH:46][CH:45]=1

Participants

3

Reactant 2

HCID 5789ThymidineHCID 136395924N2 Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Product 1

HCID 1624195'-O-(4,4'-Dimethoxytrityl)thymidine

Procedure

This compound was prepared from thymidine by the same procedure used for the preparation of N2 -isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine.

Sources & evidence

ORD record
ord-50ab210510114f18a5fe1ce960b80705
Source dataset
uspto-grants-1997_09
Patent number
US05672697

Reaction notes

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