N-(9-((2S,3R,4S,5S)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide → 9-(3-O-t-Butyldimethylsilyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-N2-isobutyrylguanine

Participants

Role	Name	HCID	Charge
Reactant	N-(9-((2S,3R,4S,5S)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide	HCID 136395928	—
Reactant	N-(9-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-3H-purin-2-yl)isobutyramide	HCID 136483518	—
Product	9-(3-O-t-Butyldimethylsilyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-N2-isobutyrylguanine	HCID 137231665	—

Reaction Steps

This compound is prepared from 9-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-2-fluoro-β-D-arabinofuranosyl]-N2 -isobutyrylguanine by the same procedure used for the preparation of 3'-O-t-butyldimethylsilyl-N2 -isobutyryl-2'-deoxyguanosine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05672697
Source dataset	uspto-grants-1997_09
ORD ID	ord-1a8defbc63684dde827937cd4db38615
Source note	uspto-grants-1997_09