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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1379778Generated: October 27, 2026

3'-O-(t-butyldimethylsilyl)thymidine → 1-(3-O-t-Butyldimethylsilyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-thymine

https://huagongshe.com/reaction/1379778

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3'-O-(t-butyldimethylsilyl)thymidineHCID 453844—
ReactantHCID 86751361HCID 86751361—
Product1-(3-O-t-Butyldimethylsilyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-thymineHCID 22877489—

Reaction Steps

This compound is prepared from 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-2-fluoro-β-D-arabinofuranosyl]-thymine by the same procedure used for the preparation of 3'-O-t-butyldimethylsilylthymidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05672697
Source datasetuspto-grants-1997_09
ORD IDord-8519ac39abc740cd859a106b892c0f35
Source noteuspto-grants-1997_09