Methanol → HCID 9820836, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 95 mg (0.23 mmol) of ethyl 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylsulfonyl)benzoate (Compound 4) in 4.0 mL of tetrahydrofuran was added 1.0 mL of LiOH (2.6N aqueous solution) and 1.4 mL of MeOH. The solution was heated at 55° C. for 2.5 h, cooled to room temperature and concentrated in vacuo. The residue was diluted with brine, acidified to pH=1 using 10% HCl and extracted with ether (2×). The combined organic layers were washed with brine, dried (MgSO4), filtered and the solvents were removed in vacuo to give the title compound as a white solid (80 mg, 91%):

Provenance & Evidence