Methanol → HCID 86751362, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 58 mg (0.15 mmol) of ethyl 4-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthylsulfoxy)benzoate (Compound 8) in 4.0 mL of tetrahydrofuran was added 1.0 mL of LiOH (2N aqueous solution) and 2.0 ml of MeOH. The solution was heated at 55° C. for 2 h and stirred at room temperature for 8 h. The reaction mixture was then concentrated in vacuo. The residue was diluted with brine and 10% HCl and extracted with diethyl ether (2×). The combined ether layers were dried (MgSO4), filtered, and the solvents removed in vacuo to give the title compound as a white solid (0.39 mg, 72%):

Provenance & Evidence