Water → HCID 10716721, compound

Participants

Reaction Steps

To a solution of 69 mg (0.18 mmol) of ethyl 4-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthylthio)benzoate (Compound 6) in 2.0 mL of methylene chloride was dropwise added a solution of 87 mg of m-chloroperoxybenzoic acid (0.27 mmol, 50-60%) in 2.0 mL of methylene chloride, and the resulting solution was stirred for 3 h. The reaction was diluted with water and extracted with methylene chloride (2×). The combined organic layers were dried (MgSO4), filtered, and the solvents removed in vacuo to give a white solid. The crude product was purified by flash chromatography on silica gel (9:l/hexane:ethyl acetate) to give the title compound as a white solid (51 mg, 94%):

Provenance & Evidence