2'-[(t-Butoxycarbonylamino)methyl]-1,1-biphenyl-4-methanol → HCID 22877442, compound

Participants

Reaction Steps

Prepared from 2-benzyloxycarbonylamino-2-methyl- N-[7-fluoro-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]propanamide (Step E) and 2'-[(t-butoxycarbonylamino)methyl]-1,1'-biphenyl-4-methanol, methanesulfonate ester (Example 35, Step G) according to the procedure described in Example 35, Step H. 1H NMR (200 MHz, CDCl3): δ 1.39 (s, 9H), 1.48 (s, 3H), 1.51 (s, 3H), 1.78 (m, 1H), 2.35-2.70 (m, 3H), 4.18 (d, 7 Hz, 2H), 4.42 (m, 1H), 4.58 (m, 1H), 4.75 (d, 16 Hz, 1H), 5.05 (s, 2H), 5.27 (d, 16 Hz, 1H), 5.35 (s, 1H), 6.88 (dd; 8, 6 Hz; 1H), 6.98 (m, 1H), 7.09 (d, 6 Hz,1H), 7.14-7.35 (m, 13H), 7.40 (d, 8 HZ, 1H). FAB-MS: calculated for C41H45FN4O6 708; found 709 (M+H).

Provenance & Evidence