HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1379895Generated: October 31, 2026
Methanesulfonic Acid → 5-Dimethylaminomethylfurfuryl chloride hydrochloride
https://huagongshe.com/reaction/1379895
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | ((2-(Hydroxymethyl)-5-furyl)methyl)ammonium chloride | HCID 3086123 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Dimethylaminomethylfurfuryl chloride hydrochloride | HCID 12954792 | — |
Reaction Steps
Combine 5-[(dimethylamino)methyl]-furfuryl alcohol hydrochloride (1.72 kg, 8.97 mol) and acetonitrile (4.3 L). Cool to about 10° C. Add thionyl chloride (1.02 kg, 8.54 mol) dropwise, while maintaining the temperature of the reaction at below about 40° C. After the addition of thionyl chloride is complete, add methanesulfonic acid (1.3 kg, 13.5 mol). Distill to remove about 1.8 L of distillate to give the title compound as a solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05672724 |
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| Source dataset | uspto-grants-1997_09 |
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| ORD ID | ord-82f011ea3df240f298bd03a1f2836efc |
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| Source note | uspto-grants-1997_09 |
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