HCID 11821736, compound → HCID 13028362, compound

HRID 1379900Notes

Reaction equation

HRID 1379900 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([CH3:20])[CH3:19])=[CH:13][CH:12]=1)(C(F)(F)F)[C:4]([OH:6])=[O:5].FC(F)(F)C(C1C=CC=CC=1)(C(F)(F)F)C(O)=O>>[F:1][C:2]([F:21])([F:22])[CH:3]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([CH3:19])[CH3:20])=[CH:13][CH:12]=1)[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 11821736HCID 11821736, compoundHCID 18977468HCID 18977468, compound

Product 1

HCID 13028362HCID 13028362, compoundYield 43%

Procedure

Reaction was carried out in the same manner as in Example 1, except that methyl ester of α,α-bis(trifluoromethyl)-p-isobutylphenylacetic acid obtained in Reference Example 3 was used in place of methyl ester of α,α-bis(trifluoromethyl)phenylacetic acid obtained in Reference Example 2, whereby α-(trifluoromethyl)-p-isobutylphenylacetic acid was obtained in yield of 43%.

Workup

  1. customReaction
  2. customobtained in Reference Example 3
  3. customobtained in Reference Example 2

Sources & evidence

ORD record
ord-9b4677d0ba3245df849959f5a46197fa
Source dataset
uspto-grants-1997_09
Patent number
US05672742

Reaction notes

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