Acetamide, N-(4-fluoro-3-nitrophenyl)- → 6-Methylthio-3-acetylaminonitrobenzene

HRID 1379912Notes

Reaction equation

HRID 1379912 reaction equation
[CH3:1][S-:2].[Na+].[N+:4]([C:7]1[CH:12]=[C:11]([NH:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:9][C:8]=1F)([O-:6])=[O:5]>C(COC)OC>[CH3:1][S:2][C:8]1[C:7]([N+:4]([O-:6])=[O:5])=[CH:12][C:11]([NH:13][C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 67694Acetamide, N-(4-fluoro-3-nitrophenyl)-HCID 4378561Sodium methanethiolate

Product 1

HCID 229083596-Methylthio-3-acetylaminonitrobenzene

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

At room temperature, 50.0 g of sodium thiomethoxide are suspended in 500 ml of dimethoxyethane and 99.1 g (0.5 mole) of 2-nitro-4-acetylaminofluorobenzene are added, in portions, over 30 min, while the temperature is maintained between 25° and 27° C. by means of an ice cold water bath.

Workup

  1. customAt room temperature
  2. temperatureis maintained between 25° and 27° C. by means of an ice cold water bath

Sources & evidence

ORD record
ord-cf7826db4e0e4fc48e93c596b53c0643
Source dataset
uspto-grants-1997_09
Patent number
US05672759

Reaction notes

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