HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (S)-N-Benzyl-N-methyl-2-[N-(b-butoxycarbonyl)-2-hydroxy-ethylamino]-3-phenyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (S)-N-benzyl-N-methyl-2-[N-(t-butoxycarbonyl)-2-oxo-ethylamino]-3-phenyl-propionamide | HCID 53842533 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-N-Benzyl-N-methyl-2-[N-(b-butoxycarbonyl)-2-hydroxy-ethylamino]-3-phenyl-propionamide | HCID 86751365 | — |
Reaction Steps
Combine (S)-N-benzyl-N-methyl-2-[N-(t-butoxycarbonyl)-2-oxo-ethylamino]-3-phenyl-propionamide (5.0 mmol) and sodium borohydride (5.0 mmol) in ethanol (20 mL). Stir for 16 hours. Concentrate in vacuo to obtain a residue. Dilute the residue with ethyl acetate and extract with 0.5M hydrochloric acid solution and water. Separate the layers, dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05672602 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-fe9a3f58999641d3a633fa0dcc6da3c3 |
| Source note | uspto-grants-1997_09 |