HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → Methyl 2-bromo-4-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Bromo-4-fluorophenol | HCID 605472 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-bromo-4-fluorobenzoate | HCID 7210837 | — |
Reaction Steps
2-Bromo-4-fluorophenol (28 g) was added to a solution of sodium hydroxide (7 g) in water (100 ml), and methyl chloroformate was dropwise added thereto at a temperature of below 10° C. Precipitated crystals were collected by filteration and washed with water to give methyl (2-bromo-4-fluorophenyl)formate (41 g). M.P., 80.7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04579688 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-45d65a5475bb4248b7c2a6c117a90a10 |
| Source note | uspto-grants-1986_04 |