Water → 5-Bromo-3-phenyl-2,1-benzisoxazole

HRID 1380010Notes

Reaction equation

HRID 1380010 reaction equation
[C:1]1([CH2:7][C:8]#N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].[Br:12][C:13]1[CH:18]=C[C:16]([N+:19]([O-])=[O:20])=[CH:15][CH:14]=1.O>CO>[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[C:8]([CH:18]=1)=[C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[O:20][N:19]=2

Participants

6

Reactant 4

HCID 962WaterHCID 8794PhenylacetonitrileHCID 114661-Bromo-4-nitrobenzeneHCID 14797Potassium Hydroxide

Product 1

HCID 3472905-Bromo-3-phenyl-2,1-benzisoxazoleYield 55.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
50 °C

Procedure

Phenylacetonitrile (8.1 g, 69 m mol) was added to a room temperature solution of potassium hydroxide (85%) (74 g, 1.1 mol) in methanol (150 ml). To this was added 4-bromo-1-nitrobenzene (12.7 g, 63 m mol) suspended in methanol (130 ml). An exotherm was noted and the reaction was maintained at 50° C. for 5 hrs. After cooling to room temperature, water (400 ml) was added. The precipitate was collected and washed with water. The crude product (13.15 g) was crystallized from hot methanol (200 ml) to yield yellow needles (9.52 g, mp 113°-116° C.).

Workup

  1. temperatureAfter cooling to room temperature
  2. customThe precipitate was collected
  3. washwashed with water
  4. customThe crude product (13.15 g) was crystallized from hot methanol (200 ml)

Sources & evidence

ORD record
ord-72ee624d4f1e4e03b103ccb49c0765ba
Source dataset
uspto-grants-1986_04
Patent number
US04579679

Reaction notes

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