Methyl iodide → HCID 135754930, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 9-(2-hydroxyethoxymethyl)guanine (1.0 g; 4.44 mmol) in dry DMF (50 ml) was added a solution of methyl iodide (680 mg, 4.77 mmol) in dry DMF (2 ml). This mixture was heated under a reflux condenser under N2 at 57° C. overnight. The mixture was concentrated in vacuo to an oil and the evaporation was repeated several times from MeOH. The residue was dissolved in MeOH (20 ml) and 2-propanol (150 ml) was added and the mixture was stirred overnight. A yellow solid was obtained which was filtered off (200 mg). This was recrystallized from MeOH (25 ml) (solution filtered through a little charcoal). Crystallization was induced by concentration of the solution, cooling and by the addition of a little 2-propanol.

Provenance & Evidence