Carbon Dioxide → HCID 13604343, compound

Participants

Reaction Steps

A mixture of 55.0 g of 3-phenyl-2,3,6,7-tetrahydro-5H-imidazo[2,1-b][1,3]thiazine and 540 ml of 0.5N sodium hydroxide solution is stirred and refluxed under nitrogen for thirty hours. The solution is cooled, neutralized to pH 8 with carbon dioxide and extracted with methylene chloride. The organic extracts are dried over magnesium sulfate, filtered and concentrated in vacuo to yield a colorless solid. Recrystallization from isopropyl acetate yields the product of this example, 53.8 g, m.p. 97°-99° C.

Provenance & Evidence