Sec-Butylamine → HCID 178449218, compound

HRID 1380041Notes

Reaction equation

HRID 1380041 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][N:19]([C:24]#[N:25])[C:20](=[NH:23])SC)[CH2:14][CH2:13]1.[CH:26]([NH2:30])([CH2:28][CH3:29])[CH3:27]>N1C=CC=CC=1>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][N:19]([C:24]#[N:25])[C:20]([NH:30][CH:26]([CH3:27])[CH2:28][CH3:29])=[NH:23])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 24874Sec-ButylamineHCID 131714594HCID 131714594, compound

Product 1

HCID 178449218HCID 178449218, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 3 g 1-[(2,3-dihydro[4H]1,4-benzodioxin-2-yl)methyl]4-[(N-cyano S-methyl isothioureido)methyl]piperidine, 10 ml pyridine and 30 g sec butylamine are heated to the reflux. After evaporation to dryness the resulting oily product is taken up in isopropyl ethyl allowing the recovery of a solid as colourless crystalls. They are recrystallized from isopropanol.

Workup

  1. temperatureare heated to the reflux
  2. customAfter evaporation to dryness the resulting oily product
  3. customThey are recrystallized from isopropanol

Sources & evidence

ORD record
ord-a0e010d376bf43908669586e573f9cf7
Source dataset
uspto-grants-1986_04
Patent number
US04579845

Reaction notes

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