HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 2-Methyl-4-pyridinecarboximidamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-Methylpyridine-4-carbonitrile | HCID 11959073 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methyl-4-pyridinecarboximidamide hydrochloride | HCID 13590402 | — |
Reaction Steps
A 17.2 g portion of 4-cyano-2-picoline [E. Ochiai and I. Suzuki, Pharm. Bull. (Japan), 2, 147 (1954)] was dissolved in 150 ml of methanol, 756 mg of sodium methoxide was added and the mixture was stirred overnight. A 7.9 g portion of ammonium chloride was added and the mixture was heated to reflux, then cooled to room temperature, giving 15 g of the desired compound, mp 168°-178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04579848 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-63e991bb5fed4bdb99959cfc277ac88a |
| Source note | uspto-grants-1986_04 |