Phosgene → 5-(Chloromethyl)-3-oxo-1,2-oxazole-2(3H)-carbonyl chloride

Participants

Reaction Steps

A mixture of 673 mg of 5-chloromethyl-3-hydroxyisoxazole, 19 ml of benzene and about 1 ml of liquified phosgene was stirred at room temperature for 5 hours. At the end of this time, the excess phosgene and the solvent were distilled off, giving 900 mg (yield 100% of theory) of the title compound, in the form of a colourless oil having a refractive index, nD24 =1.5391.

Provenance & Evidence