2-Bromoethylamine hydrobromide → HCID 20242091, compound

HRID 1380069Notes

Reaction equation

HRID 1380069 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][CH2:12][C:13]([OH:15])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[O-]C#N.[K+].COC1C=C([N:30]2[CH2:36][C:34](=O)[NH:33][C:31]2=[O:32])C=CC=1OC.Br.BrCCN>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:12][C:13](=[O:15])[N:30]([CH2:36][CH2:34][NH2:33])[C:31]2=[O:32])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 4

HCID 27742172-Bromoethylamine hydrobromideHCID 11378442Potassium cyanateHCID 13495854HCID 13495854, compoundHCID 20242093HCID 20242093, compound

Product 1

HCID 20242091HCID 20242091, compound

Procedure

In the same way as in [A] and reacting the N-(3,4-dimethoxyphenyl)glycine (17.2 g, 81 mmoles) with potassium cyanate (6.6 g, 81 mmoles) the 1-(3,4-dimethoxyphenyl)hydantoin was obtained, m.p. 223°-225° C. By reacting the latter (11.23 g, 47.5 mmoles) with 2-bromoethylamine hydrobromide (9.74 g, 47.5 mmoles) as described in [A] the title compound was obtained, m.p. 162°-164° C.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-a24982a089a9459b99536526bd680754
Source dataset
uspto-grants-1986_04
Patent number
US04579861

Reaction notes

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