HCID 13590325, compound → HCID 13590326, compound

HRID 1380099Notes

Reaction equation

HRID 1380099 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)([CH3:13])[C:8]2=[O:12])=[CH:4][C:3]=1[NH:19]CCO.CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[NH2:19][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([Cl:11])[C:2]=1[Cl:1])[C:8](=[O:12])[C:7]([CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)([CH3:13])[CH2:6]2

Participants

4

Reactant 2

HCID 13590325HCID 13590325, compoundHCID 131709961Jones' reagent

Product 1

HCID 13590326HCID 13590326, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A stirred solution of 6,7-dichloro-2-cyclopentyl-2,3-dihydro-5-(2-hydroxyethylamino)-2-methyl-1H-inden-1-one (2.0 g) in acetone (50 ml) is treated with Jones Reagent (3 ml) at 25° C. over a 1 hour period. The reaction mixture is allowed to stand overnight then filtered free of chromium salts. The acetone is evaporated in vacuo and the 5-amino-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2- methyl-1H-inden-1-one thus obtained (800 mg) is used in Step D without further purification.

Workup

  1. filtrationthen filtered free of chromium salts
  2. customThe acetone is evaporated in vacuo

Sources & evidence

ORD record
ord-c25555b7b40b423895f3dd5f83137404
Source dataset
uspto-grants-1986_04
Patent number
US04579869

Reaction notes

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