反应详情

To 1-morpholinocyclohexene (21.5 g; 0.13 mol) was added diphenyl phosphite (30 g; 0.13 mol) drop-wise during 20 minutes. The mixture which began to deposit a solid was heated at 100° for 30 minutes following the addition. After cooling, the resulting solid was recrystallized from benzene/hexane to yield pure diphenyl 1-morpholinocyclohexane-1-phosphonate, 37 g (70%), mp 103°-6°. NMR and IR spectra support the structure. Analysis: Calculated for C22H28NO4P; N, 3.49%; P, 7.73%. Found: N, 3.40% P, 7.70%. ##STR10##

1. temperaturewas heated at 100° for 30 minutes
2. additionthe addition
3. temperatureAfter cooling
4. customthe resulting solid was recrystallized from benzene/hexane