HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 13606716, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Cyclohexyl isocyanate | HCID 18502 | — |
| Reactant | 3-(4-benzylpiperazin-1-yl)propan-1-amine | HCID 3149269 | — |
| Product | HCID 13606716 | HCID 13606716 | 65% |
Reaction Steps
A solution of 1-(3-aminopropyl)-4-benzylpiperazine (2 g; 12.9 mmole) and cyclohexyl isocyanate (1.6 g; 12.9 mmole) in methylene chloride (50 ml) was stirred overnight at room temperature. The reaction mixture was concentrated, and the crude product was precipitated as the dihydrochloride from ether in the manner described in Example 6. Recrystallization from ethanol provided the title compound as colorless crystals (3.62 g; 65% yield), m.p. 202°-213° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04579947 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-5b27927fad70474eaf85e5f1508731e1 |
| Source note | uspto-grants-1986_04 |