HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylphenyl isocyanate → 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-(4-methylphenyl)urea dihydrochloride monohydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylphenyl isocyanate | HCID 69325 | — |
| Reactant | HCID 13606667 | HCID 13606667 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-(4-methylphenyl)urea dihydrochloride monohydrate | HCID 20205749 | 49.4% |
Reaction Steps
The procedure described in Example 3 was followed, using 1-(3-aminopropyl)-4-(4-chlorobenzyl)piperazine (2.67 g; 10 mmole), methylene chloride (50 ml) and 4-tolyl isocyanate (1.33 g; 10 mmole). Recrystallization from methanol/methylene chloride provided the title compound (0.81 g; 17% yield) as colorless crystals, m.p. 131°-132° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04579947 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-372725b149844f5ba9cbbb13eccb6abf |
| Source note | uspto-grants-1986_04 |