2-Chloroethanol → HCID 86740252, compound

Participants

Reaction Conditions

Reaction Steps

A 2 liter round bottom flask was equipped with an overhead stirrer, thermometer, condenser and addition funnel with N2Inlet. 216 g of 2-chloroethanol and 550 cc of dry chloroform were charged to the flask and chilled to -30° C. Chlorosulfonic acid was added dropwise in one hour, and the reaction was allowed to warm to room temperature and stir for 11/2 hours. With the reaction solution again at -30° C., cold methanol was added dropwise followed by 300 g of 50% NaOH solution. The reaction was heated to reflux and filtered hot. The filtrate crystallized upon standing yielding white crystals, which were filtered and washed with cold methanol to yield sodium 2-chloroethane sulfate.

Provenance & Evidence