反应详情

To a sodium methylate solution under agitation obtained by dissolving Na (2.8 g, 0.12 mol) in anhydrous methanol (20 c.c.) was added 4-fluorobenzamidine hydrochloride (10.5 g, 0.06 mol), followed by adding α-propyl-β-dimethylaminoacrolein (9.2 g, 0.06 mol), thereafter refluxing on heating for 3 hours with stirring, distilling off methanol under the atmospheric pressure after completion of the reaction, adding toluene (20cc) to the reaction residue to extract the resulting product, washing the extraction liquid with water, drying with anhydrous sodium sulfate, distilling off toluene and recrystallizing the remaining oily substance from ethanol (20 c.c.) to obtain the objective 5-propyl-2-(4-fluorophenyl)pyrimidine (7.0 g). Yield: 55%. M.P. 52.7° C.

1. temperaturerefluxing
2. temperatureon heating for 3 hours
3. distillationdistilling off methanol under the atmospheric pressure
4. customafter completion of the reaction
5. extractionto extract the resulting product
6. washwashing
7. extractionthe extraction liquid with water
8. dry with materialdrying with anhydrous sodium sulfate
9. distillationdistilling off toluene
10. customrecrystallizing the remaining oily substance from ethanol (20 c.c.)