Bromide ion → 2-(Trifluoromethyl)benzoyl chloride
Reaction equation
[F:1][C:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](F)=[O:8])([F:4])[F:3].[Cl:14]C(C1C=CC=CC=1C(Cl)=O)(Cl)Cl.BrC(C1C=CC=CC=1C(Br)=O)(Br)Br.[Br-]>>[F:1][C:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([Cl:14])=[O:8])([F:4])[F:3]Participants
Procedure
Under ideal stoichiometic conditions three moles of trifluoromethylbenzoyl fluoride are contacted with one mole of trichloromethylbenzoyl chloride or tribromomethylbenzoyl bromide in the presence of a halogen transfer catalyst to yield four moles of trifluoromethylbenzoyl chloride or bromide. It will be understood however, that greater or less than stoichiometric amounts of the reactants can be employed. Thus, in accordance with the process of this invention substituted or unsubstituted trichloromethylbenzoyl chloride or tribromomethylbenzoyl bromide may be reacted with corresponding substituted or unsubstituted trifluoromethylbenzoyl fluorides, in the presence of a halogen transfer catalyst to produce the corresponding substituted or unsubstituted trifluoromethylbenzoyl chloride or bromide.
Sources & evidence
- ORD record
- ord-70ee7774522b4711805fb2b1963f4bfa
- Source dataset
- uspto-grants-1986_04
- Patent number
- US04581179
Reaction notes
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