Potassium Iodide → HCID 23326429, compound

Participants

Reaction Steps

A solution of 3-carboxymethylthio-5-methyl-6-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-1,2,4-triazine (7.25 g) in a mixture of 10% aqueous solution of potassium hydroxide (47 ml) and methanol (47 ml) was heated at 60° for 4 hours with stirring. To the mixture were added potassium iodide (0.5 g), benzyl chloride (5.33 g), and methanol (150 ml), refluxed for 8 hours with stirring, and evaporated in vacuo. To the residue was added water and extracted with ethyl acetate. The extract was dried over magnesium sulfate and evaporated in vacuo. The oily residue was purified by column chromatography on silica gel (300 g) with ethyl acetate as an eluent to give 6-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-2-benzyl-5-methyl-1,2,4-triazin-3(2H)-one (4.47 g).

Provenance & Evidence