N-Methyloxindole → HCID 54404628, compound

HRID 1380318Notes

Reaction equation

HRID 1380318 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C:3]1=[O:11].[C:12]1(=[O:26])[N:16]([CH2:17][C:18](Cl)=[O:19])[C:15](=[O:21])[C:14]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:13]12>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:18](=[O:19])[CH2:17][N:16]3[C:15](=[O:21])[C:14]4=[CH:22][CH:23]=[CH:24][CH:25]=[C:13]4[C:12]3=[O:26])=[CH:8][CH:9]=2)[CH2:4][C:3]1=[O:11]

Participants

3

Reactant 2

HCID 6096N-MethyloxindoleHCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-

Product 1

HCID 54404628HCID 54404628, compoundYield 65.3%

Procedure

1-Methyl-2-indolinone (34.0 g) and 2-phthalimidoacetyl chloride (37.3 g) was reacted according to a similar manner to that of Example 8-(1). The object compound was purified by column chromatography on silica gel (300 g) using chloroform as an eluent to give 36.41 g of 1-methyl-5-phthalimidoacetyl-2-indolinone.

Workup

  1. customThe object compound was purified by column chromatography on silica gel (300 g)

Sources & evidence

ORD record
ord-5f5355e1e2eb4ca2a5e50fdc90f5153c
Source dataset
uspto-grants-1986_04
Patent number
US04581356

Reaction notes

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