反应详情

温度

115 °C

To 4.77 g (0.023 mole) 1-chloro-4-(4-chlorobutyl)benzene add 2.23 g (0.023 mole) 1,2-dimethyl-1H-imidazole. Stir the solution for three hours at about 115° C. Follow the progress of the reaction by thin-layer chromatography on silica gel (MEOH:NaCL(1M), 92:8). At the completion of the reaction, cool to obtain an oil. Triturate the oil with petroleum ether until a solid precipitates. Recrystallize the solid from MeOH/acetone; filter and dry in vacuo to yield the title compound as a monohydrate.

1. customthe progress of the reaction by thin-layer chromatography on silica gel (MEOH:NaCL(1M), 92:8)
2. customAt the completion of the reaction
3. temperaturecool
4. customto obtain an oil
5. customTriturate the oil with petroleum ether until a solid
6. customprecipitates
7. customRecrystallize the solid from MeOH/acetone
8. filtrationfilter
9. customdry in vacuo