1-Methylimidazole → HCID 178480862, compound

HRID 1380361Notes

Reaction equation

HRID 1380361 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11]Cl)=[CH:4][CH:3]=1.[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[Cl-:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N+:16]2[CH:17]=[CH:18][N:14]([CH3:13])[CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 13901-MethylimidazoleHCID 200827321-Chloro-4-(4-chlorobutyl)benzene

Product 1

HCID 178480862HCID 178480862, compound

Procedure

Combine 6.1 g (0.03 mole) 1-chloro-4-(4-chlorobutyl)benzene with 2.5 g (0.03 mole) 1-methyl-1H-imidazole and heat at 120° C., following the course of the reaction by thin-layer chromatography on silica gel (methanol:1M sodium chloride, 95:5). At the completion of the reaction, cool and triturate with ether, collect the solid and recrystallize from 50 ml hot acetone to obtain the title compound.

Workup

  1. customthe course of the reaction by thin-layer chromatography on silica gel (methanol:1M sodium chloride, 95:5)
  2. customAt the completion of the reaction
  3. temperaturecool
  4. customtriturate with ether
  5. customcollect the solid
  6. customrecrystallize from 50 ml hot acetone

Sources & evidence

ORD record
ord-554b5d030573415f9be95bab0484c6b7
Source dataset
uspto-grants-1986_04
Patent number
US04581370

Reaction notes

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